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Hiroshi Tazawa Selected Research

Telomerase (Telomerase Reverse Transcriptase)

6/2022Tumor-targeted fluorescence labeling systems for cancer diagnosis and treatment.
4/2022Overexpression of Adenovirus E1A Reverses Transforming Growth Factor-β-induced Epithelial-mesenchymal Transition in Human Esophageal Cancer Cells.
10/2021Local oncolytic adenovirotherapy produces an abscopal effect via tumor-derived extracellular vesicles.
5/2021Telomerase-specific oncolytic immunotherapy for promoting efficacy of PD-1 blockade in osteosarcoma.
1/2021Real-Time Fluorescence Image-Guided Oncolytic Virotherapy for Precise Cancer Treatment.
9/2020Elimination of MYCN-Amplified Neuroblastoma Cells by Telomerase-Targeted Oncolytic Virus via MYCN Suppression.
6/2020Oncolytic Virus-Mediated Targeting of the ERK Signaling Pathway Inhibits Invasive Propensity in Human Pancreatic Cancer.
2/2020Bone and Soft-Tissue Sarcoma: A New Target for Telomerase-Specific Oncolytic Virotherapy.
10/2018Integrated fluorescent cytology with nano-biologics in peritoneally disseminated gastric cancer.
11/2017Therapeutic Cell-Cycle-Decoy Efficacy of a Telomerase-Dependent Adenovirus in an Orthotopic Model of Chemotherapy-Resistant Human Stomach Carcinomatosis Peritonitis Visualized With FUCCI Imaging.
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Hiroshi Tazawa Research Topics

Disease

79Neoplasms (Cancer)
06/2022 - 03/2002
16Stomach Neoplasms (Stomach Cancer)
06/2022 - 01/2005
15Neoplasm Metastasis (Metastasis)
06/2022 - 03/2002
9Inflammation (Inflammations)
11/2020 - 12/2003
9Carcinogenesis
02/2019 - 12/2005
7Infections
06/2022 - 11/2010
7Osteosarcoma (Osteogenic Sarcoma)
05/2021 - 03/2013
6Esophageal Neoplasms (Esophageal Cancer)
04/2022 - 10/2016
6Sarcoma (Soft Tissue Sarcoma)
03/2021 - 01/2007
5Fibrosarcoma
01/2021 - 03/2002
5Hypoxia (Hypoxemia)
01/2017 - 08/2012
5Foreign Bodies (Foreign Body)
05/2014 - 12/2003
4Lymphatic Metastasis
01/2022 - 06/2010
4Adenocarcinoma
05/2014 - 01/2005
3Acidosis
01/2021 - 10/2012
3Hypercapnia
01/2017 - 08/2012
3Colonic Neoplasms (Colon Cancer)
03/2015 - 09/2007
2Rectal Neoplasms (Rectal Cancer)
10/2021 - 03/2015
2Hyperthermia
01/2021 - 01/2021
2Femoral Fractures (Femoral Fracture)
11/2020 - 01/2018
2Colorectal Neoplasms (Colorectal Cancer)
01/2019 - 06/2010
2Leukemia
09/2017 - 08/2007
2Melanoma (Melanoma, Malignant)
08/2017 - 07/2006
2Triple Negative Breast Neoplasms
01/2017 - 12/2016
2Breast Neoplasms (Breast Cancer)
08/2016 - 02/2015
2Glioma (Gliomas)
03/2016 - 06/2012
2Disease Progression
04/2015 - 02/2015
2Adenoma (Adenomas)
05/2014 - 11/2013
2Respiratory Acidosis
10/2012 - 08/2012
2Lymphoma (Lymphomas)
08/2007 - 10/2004
1Hip Osteoarthritis (Coxarthrosis)
01/2021
1Pancreatic Neoplasms (Pancreatic Cancer)
01/2021

Drug/Important Bio-Agent (IBA)

30Telomerase (Telomerase Reverse Transcriptase)IBA
06/2022 - 06/2010
11Proteins (Proteins, Gene)FDA Link
06/2022 - 11/2010
10Indicators and Reagents (Reagents)IBA
01/2021 - 04/2011
8Green Fluorescent ProteinsIBA
01/2021 - 03/2015
6Biological ProductsIBA
06/2022 - 12/2005
6Biomarkers (Surrogate Marker)IBA
06/2022 - 10/2009
6Pharmaceutical PreparationsIBA
03/2017 - 09/2007
5Paclitaxel (Taxol)FDA LinkGeneric
06/2022 - 01/2014
5Red Fluorescent ProteinIBA
01/2021 - 05/2015
5Methylnitronitrosoguanidine (MNNG)IBA
01/2021 - 04/2011
5Trastuzumab (Herceptin)FDA Link
01/2018 - 11/2012
5AcidsIBA
01/2017 - 08/2012
5Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA
01/2007 - 10/2004
4CytokinesIBA
06/2022 - 12/2005
4Cytotoxins (Cytolysins)IBA
01/2021 - 01/2014
4IronIBA
01/2021 - 01/2016
4Transcription Factors (Transcription Factor)IBA
01/2016 - 12/2005
4Oxygen (Dioxygen)IBA
01/2013 - 12/2005
3Interleukin-6 (Interleukin 6)IBA
06/2022 - 10/2018
3adenovirus receptorIBA
01/2021 - 04/2011
3Cisplatin (Platino)FDA LinkGeneric
01/2021 - 01/2016
3Chelating AgentsIBA
01/2021 - 01/2016
3HMGB1 Protein (HMG1)IBA
01/2021 - 01/2016
3Fluorouracil (Carac)FDA LinkGeneric
01/2021 - 11/2017
3Conditioned Culture MediaIBA
01/2021 - 01/2019
3Monoclonal AntibodiesIBA
01/2021 - 01/2016
3Doxorubicin (Adriamycin)FDA LinkGeneric
01/2021 - 09/2007
3Nitric Oxide (Nitrogen Monoxide)FDA Link
11/2013 - 01/2005
3MicroRNAs (MicroRNA)IBA
03/2013 - 09/2007
3GelatinIBA
07/2006 - 12/2003
2Therapeutic UsesIBA
10/2021 - 01/2014
21-phenyl-3,3-dimethyltriazene (PDT)IBA
01/2021 - 01/2016
2Lactic Acid (Lactate)FDA LinkGeneric
01/2021 - 10/2012
2mahuang-tangIBA
01/2021 - 01/2021
2ThrombomodulinIBA
01/2021 - 01/2011
2Bovine Serum AlbuminIBA
01/2021 - 01/2021
2Photosensitizing Agents (Photosensitizers)IBA
01/2021 - 01/2016
2ferric oxide (iron oxide)IBA
01/2021 - 01/2021
2SolutionsIBA
11/2020 - 03/2015
2GoldIBA
01/2018 - 10/2017
2ProgesteroneFDA LinkGeneric
01/2017 - 12/2016
2Estrogens (Estrogen)FDA Link
01/2017 - 12/2016
2AntigensIBA
03/2016 - 02/2015
2Complementary DNA (cDNA)IBA
05/2014 - 03/2002
2pimagedine (aminoguanidine)IBA
11/2013 - 03/2006
2Messenger RNA (mRNA)IBA
04/2011 - 03/2002
2DNA (Deoxyribonucleic Acid)IBA
11/2010 - 01/2005
2Drinking WaterIBA
08/2007 - 03/2006
1VimentinIBA
06/2022
1Transforming Growth Factors (Transforming Growth Factor)IBA
04/2022
1Immune Checkpoint InhibitorsIBA
05/2021
1STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)IBA
01/2021
1IS 35IBA
01/2021
1Bicarbonates (Hydrogen Carbonate)IBA
01/2021
1Fluorescein-5-isothiocyanate (FITC)IBA
01/2021
1Hematoxylin (Haematoxylon)IBA
01/2021

Therapy/Procedure

32Therapeutics
06/2022 - 02/2011
15Drug Therapy (Chemotherapy)
06/2022 - 07/2012
10Oncolytic Virotherapy
01/2021 - 06/2010
5Immunotherapy
05/2021 - 07/2017
4Hip Replacement Arthroplasty (Total Hip Replacement)
01/2021 - 01/2019
3Chemoradiotherapy
01/2021 - 01/2012
3Transplantation
11/2017 - 08/2016
3Aftercare (After-Treatment)
11/2017 - 03/2015
3Lasers (Laser)
08/2017 - 01/2016
2Radiotherapy
03/2021 - 01/2021
1Laser Therapy (Surgery, Laser)
01/2021
1Hyperthermic Intraperitoneal Chemotherapy
01/2021